Metrics details. Genomic variability limits the efficacy of breast cancer therapy. To simplify thestudy of the molecular complexity of breast cancer, researchers have used mousemammary tumor models. However, the degree to which mouse models model human breastcancer and are reflective of the human heterogeneity has yet to be demonstratedwith gene expression studies on a large scale. To this end, we have built a database consisting of 1, mouse mammary tumorsamples from 26 different major oncogenic mouse mammary tumor models. In this dataset we identified heterogeneity within mouse models and noted asurprising amount of interrelatedness between models, despite differences in thetumor initiating oncogene.
We develop computer algorithms to aid clinicians in the interpretation of medical images and thereby improve the diagnostic process. The group has its roots in computer-aided detection of breast cancer in mammograms, and we have expanded to automated detection and diagnosis in breast MRI, ultrasound and tomosynthesis, chest radiographs and chest CT, prostate MRI, neuro-imaging and the analysis of retinal and digital pathology images. The technology we primarily use is deep learning. It is our goal to have a significant impact on healthcare by bringing our technology to the clinic. We are therefore fully certified to develop, maintain, and distribute software for analysis of medical images in a quality controlled environment MDD Annex II and ISO On this site you find information about the history of the group and our collaborations , an overview of people in DIAG, current projects , publications and theses , contact information , and info for those interested to join our team. Thira Lab is a collaboration between Radboudumc and Thirona , a spin-out company from Radboudumc, and Delft Imaging Systems , a company developing healthcare solutions for the specific needs of vulnerable communities around the world.
Recent advances in gene targeting technologies in the mouse have taken us one leap closer to understanding the genetic pathways that operate during normal mammary gland development and tumorigenesis. The possibility to delete or mutate genes specifically in mammary epithelial cells and at predetermined time points permits investigators to analyze the fates of defined cell types in the absence of confounding systemic effects. Gene deletion knockout and transgenic mice, both alone and in combination, can be used to address specific questions in developmental and cancer biology.
And some people say that how they feel now is bound up really in having been through cancer and things like that. Do you feel that having had cancer defines part of you or…? What do you…? Sort of a, you know, having had cancer stays with them a long time and it becomes part of who they are and their identity.